1. Signaling Pathways
  2. GPCR/G Protein
  3. Prostaglandin Receptor

Prostaglandin Receptor

Receptor

Prostaglandin receptor, a sub-family of cell surface seven-transmembrane receptors, are the G-protein-coupled receptors. There are currently ten known prostaglandin receptors on various cell types. Prostaglandins bind to a subfamily of cell surface seven-transmembrane receptors, G-protein-coupled receptors. These receptors are named: DP1-2-DP1, DP2 receptors, EP1-4-EP1, EP2, EP3, EP4 receptors, FP-FP, IP1-2-IP1, IP2 receptors, TP-TP receptor. The prostaglandins are a group of hormone-like lipid compounds that are derived enzymatically from fatty acids and have important functions in the animalbody. There are currently ten known prostaglandin receptors on various cell types.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-19518
    Latanoprostene bunod
    Control 99.85%
    Latanoprostene bunod (LBN), a nitric oxide (NO)-donating prostaglandin F2a analog, is a topical ophthalmic therapeutic for the reduction of intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension (OHT) .
    Latanoprostene bunod
  • HY-N3617
    Coniferin
    99.13%
    Coniferin (Laricin) is a glucoside of coniferyl alcohol. Coniferin inhibits fungal melanization. Coniferin inhibits the release of certain hormones from cells, including Prostaglandin E2 and Thromboxane B2.
    Coniferin
  • HY-10797
    CJ-42794
    Antagonist 98.96%
    CJ-42794 (CJ-042794) is a potent, orally active, selective prostaglandin E receptor 4 (EP4) antagonist with an IC50 value of 10 nM, which is 200-fold more selective than EP1, EP2 and EP3. CJ-42794 can be used in research of gastric ulcers.
    CJ-42794
  • HY-105218A
    Ifetroban sodium
    Antagonist 99.83%
    Ifetroban (BMS-180291) sodium is an orally active antagonist of thromboxane A2 (TXA2) or prostaglandin H2 (PGH2) receptor. Ifetroban sodium shows antiplatelet activity, and inhibits tumor cell migration without affecting cell proliferation. Ifetroban sodium can be used for myocardial ischemia, hypertension, stroke, thrombosis, cardiomyopathy research.
    Ifetroban sodium
  • HY-16504
    Treprostinil sodium
    Agonist 99.78%
    Treprostinil (UT-15) sodium is a potent DP1 and EP2 agonist with EC50 values of 0.6±0.1 and 6.2±1.2 nM, respectively.
    Treprostinil sodium
  • HY-10794
    MF498
    Antagonist 99.26%
    MF498 is a selective and orally active E prostanoid Receptor 4 (EP4) antagonist with a Ki value of 0.7 nM. MF498 can be used in the research of inflammation, such as rheumatoid and osteoarthritis.
    MF498
  • HY-101987
    BW 245C
    Agonist 99.73%
    BW 245C is a prostanoid DP-receptor (DP1) agonist, used to treat stroke.
    BW 245C
  • HY-10413
    MK-2894
    Antagonist 99.31%
    MK-2894 is a potent, selective, orally active and high affinity (Ki=0.56 nM) full antagonist against E prostanoid receptor 4 (EP4 receptor) (IC50=2.5 nM). MK-2894 possesses potent anti-inflammatory activity in animal models of pain/inflammation and can be used for the research of arthritis.
    MK-2894
  • HY-100009
    Ufenamate
    Inhibitor 99.89%
    Ufenamate (Flufenamic acid butyl ester) is an anthranilic acid-based anti-inflammatory drug that can be used in the study of skin diseases such as acute and chronic eczema, contact dermatitis, diaper dermatitis, miliary rashes and atopic dermatitis. Ufenamate has a certain photoprotective effect, reduces the degree of skin erythema and swelling in the photoaging model, downregulates the expression level of COX-2 and can promote the healing of mouse skull defects by secreting BMP2.
    Ufenamate
  • HY-108562
    SC-51322
    Antagonist 98.90%
    SC-51322 is a potent and selective antagonist of prostaglandin E2 (PGE2) receptor (EP 1), with a pA2 of 8.1. SC-51322 has the pain-relieving effect.
    SC-51322
  • HY-111271
    L 888607
    Agonist 99.87%
    L 888607 is a potent, selective, stable and orally active CRTH2 agonist. L 888607 has high affinity for the human CRTH2 receptor with a Ki value of 4 nM. L 888607 can be used for the research of several physiological events and metabolite.
    L 888607
  • HY-100448A
    Butaprost
    Agonist 99.2%
    Butaprost is a selective prostaglandin E receptor (EP2) agonist with an EC50 of 33 nM and a Ki of 2.4 μM for murine EP2 receptor. Butaprost is less activity against murine EP1, EP3 and EP4 receptors. Butaprost attenuates fibrosis by hampering TGF-β/Smad2 signalling.
    Butaprost
  • HY-B0428
    Ozagrel
    Inhibitor 99.74%
    Ozagrel (OKY-046)is an anti-asthmatic agent and a thromboxane A2 (TXA2) synthase inhibitor. Ozagrel is an antiplatelet agent, which selectively inhibits human platelet aggregation with an IC50 of 53.12 μM.
    Ozagrel
  • HY-106961
    ONO 1301
    Agonist 99.06%
    ONO 1301 (ONO-AP 500-02), a prostaglandin (PG) I2 mimetic, is an orally active, long-acting prostacyclin agonist with thromboxane-synthase inhibitory activity. ONO 1301 promotes production of hepatocyte growth factor (HGF) from various cell types and ameliorates ischemia-induced left ventricle dysfunction in the mouse, rat and pig.
    ONO 1301
  • HY-113331
    Thromboxane B2
    Control 99.00%
    Thromboxane B2 is a prostaglandin derivative that is released during anaphylaxis. Thromboxane B2 induces arterial contraction and platelet aggregation.
    Thromboxane B2
  • HY-14973
    Vidupiprant
    Antagonist 98.33%
    Vidupiprant (AMG 853) is a phenylacetic acid derivative. Vidupiprant is a potent and orally active CRTH2 (DP2) and prostanoid D receptor (DP or DP1) dual antagonist with IC50s of 3 nM and 4 nM in buffer, and 8 nM and 35 nM in human plasma, respectively. Vidupiprant has the potential for asthma treatment.
    Vidupiprant
  • HY-A0221
    Ridogrel
    Inhibitor 99.64%
    Ridogrel (R 68070) is an orally active combined thromboxane A2 synthetase inhibitor and thromboxane A2/prostaglandin endoperoxide receptor blocker. Ridogrel is potent antiplatelet agent. Anti-inflammatory activities.
    Ridogrel
  • HY-133123
    EP4 receptor antagonist 1
    Antagonist 99.66%
    EP4 receptor antagonist 1 is a highly potent and selective competitive prostanoid EP4 receptor antagonist for cancer immunotherapy. EP4 receptor antagonist 1 inhibits human and mouse EP4 receptor with IC50s of 6.1 nM and 16.2 nM, respectively. IC50s >10 μM for human EP1, EP2,and EP3 receptors.
    EP4 receptor antagonist 1
  • HY-112322
    Carbacyclin
    Agonist 98.00%
    Carbacyclin is a PGI2 analogue, acts as a prostacyclin (PGI2) receptor agonist and vasodilator, and potently inhibits platelet aggregation.
    Carbacyclin
  • HY-153129
    EP2 receptor antagonist-2
    Antagonist 98.69%
    EP2 receptor antagonist-2 (CID891729) is an antagonist of EP2 receptor. EP2 receptor antagonist-2 inhibits the EP2 receptor activation induced by PGE2. EP2 receptor antagonist-2 also suppresses lactate dehydrogenase (LDH) release induced by N-methyl-D-aspartate (NMDA).
    EP2 receptor antagonist-2
Cat. No. Product Name / Synonyms Application Reactivity

DP

EP

FP

IP

TXA2/TP

TXB2

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

Prostaglandin Receptor Inhibitors, Agonists, Antagonists, Activators & Modulators
Product NameDPEPFPIPTXA2/TPTXB2Purity    
Prostaglandin E2 
EP
    99.76%
Prostaglandin E1 
EP
    99.76%
U-46619    
TXA2/TP
 ≥99.0%
Prostaglandin D2
DP
     99.5%
Dinoprost  
FP Receptor
   99.63%
Tranilast
DP2, IC50: 0.1 mM
     99.58%
PF-04418948 
EP2, IC50: 16 nM
    99.40%
ONO-AE3-208 
EP4, Ki: 1.3 nM
EP3, Ki: 30 nM
FP, Ki: 790 nM
 
TP Receptor, Ki: 2400 nM
 98.65%
Latanoprost  
FP Receptor
   99.85%
Treprostinil  
FP Receptor, Ki: 4680 nM
IP Receptor, EC50: 1.9 nM
IP Receptor, Ki: 32.1 nM
TP Receptor, EC50: 919 nM
 99.98%
Selexipag   
hIP, Ki: 260 nM
  99.86%
Iloprost   
IP
  99.76%
L-798106 
EP3, IC50: 0.3 nM
EP4, IC50: 916 nM
EP1, IC50: >5000 nM
EP2, IC50: >5000 nM
    99.81%
DG-041 
EP3, IC50: 4.6-8.1 nM
    ≥99.0%
16,16-Dimethyl prostaglandin E2 
EP2
EP4
    ≥99.0%
L-161982 
EP4
    99.04%
Laropiprant
DP, Ki: 0.57 nM
   
TP Receptor, Ki: 2.95 nM
 99.93%
Grapiprant 
dog EP4, IC50: 35 nM
dog EP4, Ki: 24 nM
    99.57%
Asapiprant
DP1, Ki: 0.44 nM
     99.53%
RO1138452   
Rat I2 Receptor, IC50: 7 nM
Rat I2 Receptor, pKi: 8.33
  ≥98.0%
GW627368 
EP
    99.81%
Ginsenoside Ro    
TXA2
 99.81%
Travoprost  
FP
   99.99%
Ramatroban
hDP2, IC50: 113 nM
hDP2, IC50: 33.4 μM
   
hTP, IC50: 14 nM
 99.10%
Prostaglandin E2-d4 
EP
    99.90%
Cefminox sodium   
IP Receptor
  99.83%
Omidenepag 
hEP4, IC50: 5480 nM
hEP2, IC50: 10 nM
hEP2, EC50: 1.1 nM
    99.67%
L-902688 
EP4, Ki: 0.38 nM
EP4, EC50: 0.6 nM
    ≥99.0%
Seratrodast    
TXA2/TP
 98.86%
Nedocromil
PGD2
     98.75%
NTP42    
TXA2
 98.58%
MRE-269   
IP Receptor
  99.91%
Ebopiprant  
Human FP Receptor, Ki: 1 nM
Rat FP Receptor, Ki: 26 nM
   98.65%
Pectolinarin 
EP
    99.89%
Fevipiprant
DP2, Kd: 1.14 nM
     99.38%
AZD1981
DP
     99.37%
Beraprost sodium   
IP
  99.88%
Omidenepag isopropyl 
EP2
    99.20%
TG4-155 
EP2, Ki: 9.9 nM
    99.91%
Prostaglandin J2
hDP, Ki: 0.9 nM
hCRTH2, Ki: 6.6 nM
hEP1, Ki: 15.678 μM
hEP2, Ki: 989 nM
hEP3, Ki: 319 nM
hEP4, Ki: 1065 nM
hFP, Ki: 553 nM
hIP, Ki: >25 μM
hTP, Ki: 6426 nM
 98.10%
Timapiprant
DP
     99.48%
Prostaglandin E2 (Standard) 
EP
    
p-Hydroxycinnamic acid     
TXB2, IC50: 371 μM
99.94%
CJ-42794 
EP, EC50: 10 nM
    98.96%
Treprostinil sodium
DP1, EC50: 0.6±0.1 nM
DP1, Ki: 4.4 nM
EP2, EC50: 6.2±1.2 nM
EP2, Ki: 3.6 nM
EP4, Ki: 826 nM
EP3, Ki: 2505 nM
EP1, Ki: 212 nM
EP1, EC50: 285 nM
EP3, EC50: 68.9 nM
EP4, EC50: 181 nM
FP Receptor, Ki: 4680 nM
IP Receptor, EC50: 1.9 nM
IP Receptor, Ki: 32.1 nM
TP Receptor, EC50: 919 nM
 99.78%
MF498 
EP4, Ki: 0.7 nM
    99.26%
BW 245C
DP
     99.73%
SC-51322 
EP2, pA2: 8.1
    98.90%
L 888607
DP, Ki: 0.8 nM
 
FP Receptor, Ki: 10018 nM
IP Receptor, Ki: 14434 nM
TP Receptor, Ki: 283 nM
 99.87%
Ozagrel    
TXA2
 99.74%
Ridogrel 
EP
    99.64%
Carbacyclin   
PGI2 Receptor
  98.00%
EP2 receptor antagonist-2 
EP
    98.69%
Latanoprost acid  
FP
   99.62%
Evatanepag 
EP2
    99.78%
MF-766 
EP4, Ki: 0.23 nM
    99.69%
Licarin A
DP
     98.48%
(+)-Cloprostenol  
PGF
   99.28%
CAY10471 Racemate
CRTH2, Ki: 0.6 nM
     99.00%
Dinoprost tromethamine salt  
FP Receptor
   ≥98.0%
EP3 antagonist 3 
EP3, pKi: 8.3
    99.52%
Setipiprant
hCRTH2, IC50: 6 nM
hDP1, IC50: 1290 nM
EP2, IC50: 2600 nM
    98.23%
Sulprostone 
EP3
    ≥99.0%
Epibetulinic acid 
EP2, IC50: 0.6 μM
    ≥98.0%
PDC31  
FP Receptor, Ki: ~30 nM
   99.76%
Ozagrel hydrochloride    
TXA2/TP
 99.68%
SC 51089 free base 
EP1, Ki: 1.3 μM
EP3, Ki: 17.5 μM
FP, Ki: 61.1 μM
 
TP, Ki: 11.2 μM
 98.64%
EP2 receptor antagonist-1 
EP2
    99.45%
EP4 receptor agonist 2 
EP4, EC50: 0.8 nM
EP2, Ki: >100000 nM
EP3, Ki: 38000 nM
EP4, Ki: 3.1 nM
    ≥99.0%
Ralinepag
hDP1, EC50: 850 nM
  
hIP, EC50: 8.5 nM
rIP, EC50: 530 nM
  99.79%
L-826266 
EP3
    ≥98.0%
BI-671800
hCRTH2, IC50: 4.5 nM
mCRTH2, IC50: 3.7 μM
     99.36%
Taprenepag isopropyl 
EP2
    99.23%
BAY-6672 hydrochloride  
FP
   98.44%
BAY 73-1449   
IP Receptor, IC50: <0.1 nM
  99.99%
Ozagrel sodium    
TXA2
 99.98%
MK-7246
DP, Ki: 2.5 nM
   
TP, Ki: 3804 nM
 99.63%
Treprostinil palmitil
DP
     99.62%
SC-19220 
EP
    99.71%
Picotamide    
TXA2/TP
 99.76%
BW A868C
DP2
     99.00%
AAT-008 
EP4, Ki: 0.97 nM
EP4, IC50: 6.1 nM
    98.55%
Misoprostol acid 
EP
    ≥99.0%
CAY10580 
EP4, Ki: 35 nM
EP2, Ki: 3000 nM
EP3, Ki: 2000 nM
EP1, Ki: >3000 nM
    
Darbufelone mesylate  
PGF
   99.65%
Pexopiprant
DP2, Ki: <100 nM
     99.40%
PROTAC(H-PGDS)-7
DP
     99.42%
EP4-IN-1 
EP4
    99.94%
15-keto-Prostaglandin F2a  
FP
   99.2%
AMG-009
DP, IC50: 12 nM
CRTH2, IC50: 3 nM
     98.08%
PGN-9856 
EP2, pEC50: ≥ 8.5
EP2, pKi: ≥ 8.3
    98.90%
Pizuglanstat
DP
     99.70%
BAY-1316957 
human EP4-R, IC50: 15.3 nM
    99.73%
Aganepag isopropyl 
EP
    98.61%
Nedocromil sodium
DP
     
KW-8232 
EP
    98.10%
Tafluprost acid 
EP3, IC50: 67 nM
Human FP Receptor, Ki: 0.4 nM
Human FP Receptor, EC50: 0.53 nM
   99.80%
Daltroban    
TXA2
 98.1%
Carboprost  
FP
   99.83%
Tiaprost  
PGF
   ≥98.0%
KP496    
TXA2 Receptor
 99.79%
BGC-20-1531 free base 
EP4, pKd: 7.6
    98.05%
KW-8232 free base 
EP
    
Aganepag 
EP2, EC50: 0.19 nM
    99.71%
Treprostinil diethanolamine
DP1, Ki: 4.4 nM
EP2, Ki: 3.6 nM
EP1, Ki: 212 nM
EP4, Ki: 826 nM
EP3, Ki: 2505 nM
FP, Ki: 4680 nM
IP, Ki: 32.1 nM
  99.44%
Taprostene   
IP
  
17-Phenyl-ω-trinor-PGE2 
EP1
EP3
    ≥98.0%
L 888607 Racemate
DP1, Ki: 132 nM
   
TP, Ki: 17 nM
 99.81%
Prostaglandin D2-d9
DP
     ≥99.0%
Selexipag-d7   
IP
  98.44%
Rivenprost 
EP4, Ki: 0.7 nM
    ≥99.0%
CAY10471
CRTH2
     
SC 51089 
EP1, Ki: 1.3 μM
EP3, Ki: 17.5 μM
FP, Ki: 61.1 μM
 
TP, Ki: 11.2 μM
 
GSK-269984A 
EP1, pIC50: 7.9
    99.74%
Carboprost tromethamine  
FP
   99.85%
ONO-8711 
EP
    
Tranilast sodium
DP2, IC50: 0.1 mM
     
Iloprost-d4   
IP
  
Sulotroban    
TXA2 Receptor
 
EP4 receptor antagonist 2 
EP4, IC50: 7.8 nM
    
Ifetroban    
TXA2/TP
 99.65%
Cicaprost   
IP
  
BAY-6672  
FP
   
Laropiprant sodium
DP, Ki: 0.57 nM
   
TP, Ki: 2.95 nM
 
MK-8318
DP, Ki: 5.0 nM
     
GSK345931A 
EP1
    
Prostaglandin E1-d9 
EP
    
(R)-Vorbipiprant 
hEP4, Ki: 16.6 nM
    
Selexipag-d6   
IP
  
L-644698
hDP receptor, Ki: 0.9 nM
hEP2, Ki: 267 nM
hEP3, Ki: 3730 nM
hEP4, Ki: 9280 nM
    
MK-447   
PGI2
  
ASP7657 free base 
hEP4, IC50: 2.21 nM
rat EP4, IC50: 6.02 nM
    
Nocloprost 
EP1
EP3
    
Travoprost (Standard)  
FP
   
I-SAP    
TXA2 Receptor
 
2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide   
PGI2
  
Treprostinil-13C2,d
DP
EP
    
Prostaglandin E2-d9 
EP
    
Prostaglandin E1 (Standard) 
EP
    
EP4 receptor agonist 1 
hEP4, pEC50: 6.3
    
Cloprostenol isopropyl ester  
FP
   
Misoprostol acid-d5 
EP
    
TP-16 
EP4, IC50: 2.1 nM
    
AGN 210676
hDP receptor, EC50: 7749 nM
EP2, EC50: 5 nM
hEP3, EC50: 153 nM
    
CAY10535  
FP Receptor
 
TP Receptor
 
Prostaglandin F2α dimethyl amine  
FP
   
AMX12006 
hEP4, IC50: 4.3 nM
    
TG6-129 
EP
    
Prostaglandin D2-d4
DP
     
Saikogenin D 
EP
    99.99%
CAY10595
DP, Ki: 10 nM
     
Ramatroban-d4    
TXA2/TP
 
Latanoprost (Standard)  
FP Receptor
   
EP3 antagonist 6 
EP3, IC50: 1.9 nM
    
ICI 192605    
TXA2/TP
 
Etersalate    
TXA2
 
Terbogrel    
TXA2/TP
 
BM567    
TXA2 Receptor, IC50: 1.1 nM
TXA2 synthase, IC50: 12 nM
 
8-iso-15-keto Prostaglandin F2α  
FP
   
11-Deoxy-16,16-dimethyl-PGE2 
EP2
EP3
    
ER-819762 
EP4, IC50: 70 nM
    
Thromboxane A2    
TP
 
EP2 receptor agonist 4 
EP2, EC50: 43 nM
    
L 657925    
TXA2
 
Prostaglandin A3 
EP2, IC50: 120 nM
EP4, IC50: 20 nM
    
CAY10509  
FP, IC50: 30 nM
   
CRTH2-IN-1
hDP2, IC50: 6 nM
hDP1, IC50: 1 μM
     
LCB-2853    
TXA2 Receptor
 
AZ-1355   
Prostaglandin I2
TXA2/TP
 98.19%
RS-601    
TXA2 Receptor
 
CGS 15435    
TXA2, IC50: 1 nM
 
BGC-20-1531 
EP4
    
CI-949     
TXB2, IC50: 0.1 μM
YM158 free base    
TXA2 Receptor, pA2: 8.81
 
Bunaprolast     
TXB2
KF 13218     
TXB2, IC50: 5.3 nM